The aim of this study was to assess the efficiency of exercise tests i
n identifying ischaemia in the territories supplied by the three main
coronary arteries. We prospectively analysed 578 patients with single
vessel coronary disease (>50% stenosis in one vessel and completely no
rmal other vessels). Patients with single vessel coronary artery disea
se were divided into three groups: patients with significant left ante
rior coronary artery disease (group 1, n=234); patients with significa
nt right coronary artery disease (group 2, n=201); patients with signi
ficant left circumflex disease (group 3, n=143). Our study, which is t
he largest prospective study of patients with angiographically documen
ted single vessel coronary artery disease, suggests that the exercise
electrocardiogram is a poor predictor of circumflex coronary artery is
chaemia. In addition, the site of ST depression identified from the el
ectrocardiogram was a poor predictor of the site of myocardial ischaem
ia. No single lead could distinguish between the three groups and the
location of coronary stenosis could not be predicted by location of ST
depression.