Am. Miller et al., THE ROLE OF HUMAN-PAPILLOMAVIRUS IN THE DEVELOPMENT OF PYOGENIC GRANULOMAS, International journal of dermatology, 36(9), 1997, pp. 673-676
Background Pyogenic granulomas (lobular capillary hemangiomas) and con
dyloma acuminata share similar locations and risk factors. Human papil
lomavirus (HPV) types 6 and II are commonly associated with condyloma
acuminata, but their association with pyogenic granulomas has not been
evaluated. The purpose of this study was to determine whether pyogeni
c granulomas contain evidence of infection with condyloma-producing HP
Vs. Methods Polymerase chain reaction assays for the E6 and E7 gene se
quences of HPV types 6 and 11 and another assay for the E7 region of H
PV types 16, 31, 33, 35, 42, and 58 were used to evaluate deoxyribonuc
leic acid (DNA) extracted from archival pyogenic granuloma biopsies ta
ken from cutaneous and oral epithelium. Results Neither cutaneous nor
oral pyogenic granulomas contain amplifiable E6 or E7 sequences from a
ny of these viruses. Conclusions Pyogenic granulomas are not caused by
HPV 6, 11, 16, 31, 33, 35, 42, or 58. This study does not exclude the
possibility that other viruses may be responsible for these tumors.