SYNTHESIS OF THE BIFUNCTIONAL CHELATING AGENT ETRA-AZACYCLOTETRADECANE-N,N',N'',N'''-TETRAACETIC ACID (H2NBN-TETA)

Authors
MOREAU P TINKL M TSUKAZAKI M BURY PS GRIFFEN EJ SNIECKUS V MAHARAJH RB KWOK CS SOMAYAJI VV PENG Z SYKES TR NOUJAIM AA
Citation
P. Moreau et al., SYNTHESIS OF THE BIFUNCTIONAL CHELATING AGENT ETRA-AZACYCLOTETRADECANE-N,N',N'',N'''-TETRAACETIC ACID (H2NBN-TETA), Synthesis, (9), 1997, pp. 1010
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
9
Year of publication
1997
Database
ISI
SICI code
0039-7881(1997):9<1010:SOTBCA>2.0.ZU;2-G
Abstract
An improved, five-step synthesis (7 % overall yield) of nobenzyl)-1,4, 8,11-tetraazacyclotetradecane-N,N',N '',N'''-tetraacetic acid (H2NBn-T ETA, 6), an azamacrocyclic ligand used as a radionuclide carrier in ca ncer chemotherapy, is reported and its complete characterization and p urification is for the first time described.