ADAMANTYLATION AND ADAMANTYLALKYLATION OF AMIDES, NITRIDES AND UREAS IN TRIFLUOROACETIC-ACID

Authors
SHOKOVA E MOUSOULOU T LUZIKOV Y KOVALEV V
Citation
E. Shokova et al., ADAMANTYLATION AND ADAMANTYLALKYLATION OF AMIDES, NITRIDES AND UREAS IN TRIFLUOROACETIC-ACID, Synthesis, (9), 1997, pp. 1034
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
9
Year of publication
1997
Database
ISI
SICI code
0039-7881(1997):9<1034:AAAOAN>2.0.ZU;2-9
Abstract
A new preparative method for N-adamantylation of carboxylic acid amide s, ureas and for C5-adamantylation of barbituric acid in trifluoroacet ic acid (TFA) is proposed. Tertiary 1-adamantanols and 1-(1-adamantyl) alkanols were used as adamantylating agents. The reaction of 1-(1-adam antyl)alkanols with nitriles in TFA solution was employed for the firs t time for the preparation of N-[1-(1-adamantyl)alkyl]amides.