A SHORT EFFICIENT SYNTHESIS OF 11-MONOACETATE OF DRIMANE-8-ALPHA,11-DIOL FROM NORAMBREINOLIDE

Citation
Ki. Kuchkova et al., A SHORT EFFICIENT SYNTHESIS OF 11-MONOACETATE OF DRIMANE-8-ALPHA,11-DIOL FROM NORAMBREINOLIDE, Synthesis, (9), 1997, pp. 1045
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00397881
Issue
9
Year of publication
1997
Database
ISI
SICI code
0039-7881(1997):9<1045:ASESO1>2.0.ZU;2-O
Abstract
An efficient two-step synthesis of 11-acetoxydrimane-8 alpha-ol, a val uable intermediate for the synthesis of naturally occuring drimanes, f rom commercially available norambreinolide, is described. The Baeyer-V illiger oxidation of the initially obtained 8 alpha-hydroxy-12-oxo-11- homodrimane is considered as the key step.