PROSPECTIVE-STUDY OF THE FEATURES, INDICATIONS, AND SURGICAL-TREATMENT IN 513 CONSECUTIVE PATIENTS AFFECTED BY CROHNS-DISEASE

Background. The aim of this prospective study was to elucidate the fea tures, indications, and surgical treatment in patients affected by com plications of Crohn's disease. Methods. Between January 1985 and July 1996, 513 consecutive patients (248 male, 265 female; mean age, 38 yea rs) were operated on for 542 occurrences of Crohn's disease. Data were collected prospectively. Results. Indications for abdominal surgery w ere often multiple but included failure of medical management (n = 220 ), obstruction (n = 94), intestinal fistula (n = 68), mass (n = 56), a bdominal abscess (n = 33), hemorrhage (n = 7), and peritonitis (n = 9) . Four hundred sixty-four abdominal procedures were performed, necessi tating 425 intestinal resections and 97 strictureplasties. The use of strictureplasty was more common in the second half of the study (16.0% versus 7.3%, second half versus first half; p < 0.01). Perioperative complications occurred in 75 of the 464 abdominal operations (16%). Th ere were no deaths. One hundred thirty patients (25%) required operati on for perineal complications of Crohn's disease. The presence of Croh n's disease in the rectal mucosa was associated with a higher risk for permanent stomas in patients requiring operation for treatment of per ianal Crohn's disease (67% versus 11%; p < 0.001). Conclusions. Patter ns of surgical treatment in Crohn's disease are changing, with more em phasis on nonresectional options. The presence of rectal involvement s ignificantly increases the need for a permanent stoma in patients with perianal Crohn's disease.