Background. Vaginoplasty for congenital vaginal atresia, a component o
f the Mayer-Rokitansky-Kuster syndrome, or for gender confirmation, ma
y be achieved by several techniques. This report focuses on the effica
cy of rectosigmoid neocolporrhaphy (RSNC) performed either primarily o
r secondarily after failure of another procedure. Methods. Sixty patie
nts underwent isoperistaltic RSNC, three primarily and 57 secondarily.
The indication was vaginal atresia in 1 patient and gender dysphoria
in 59 patients. Results. All 60 patients survived and have a functiona
l neovagina. One major complication, an anastomotic leak with colovagi
nal fistula, was treated by a temporary colostomy and later reconstruc
tion through a combined anterior and posterior approach. Late complica
tions were reversible stomal stenosis (six patients), reversible condu
it narrowing (five patients), transient rhabdomyoblastosis (one patien
t), and temporary mucosal bleeding from hyperplasia (three patients).
Thirty patients have regular intercourse, 12 patients have occasional
intercourse, and the others feel ''whole,'' with their intact desired
sexual anatomy awaiting a suitable partner. Conclusions. The number of
patients seeking vaginoplasty is increasing. Primary or secondary RSN
C is a safe and effective method.