Maf. Faustino et al., MESO-TETRAPHENYLPORPHYRIN DIMER DERIVATIVE AS A POTENTIAL PHOTOSENSITIZER IN PHOTODYNAMIC THERAPY, Photochemistry and photobiology, 66(4), 1997, pp. 405-412
Studies on the synthesis, preliminary irt vivo biological activity, si
nglet oxygen and fluorescence yields of a dimeric porphyrin (DI) are d
escribed. The pharmacokinetic behavior and photodynamic properties of
the dimer D1 were examined in Balb/c mice bearing an MS-2 fibrosarcoma
. Compound D1 shows a high selectivity for tumor localization (tumor/p
eritumoral tissue ratios of dye concentration ranging between ca 100 a
nd 140 at 24 h after drug administration of 5.0-1.0 mg kg(-1) into DL-
alpha-dipalmitoylphosphatidylcholine liposomes). The phototherapeutic
efficiency of dimer D1 was evaluated by following the growth curves of
fibrosarcoma irradiated with red light (600-700 mm) with a total dose
of 400 J cm(-2) at 24 h after intravenous injection. Photodynamic the
rapy-treated tumors showed a significant delay in growth as compared t
o untreated control mice. The results obtained suggest that the porphy
rin dimer D1 may be a promising candidate for further use in PDT exper
iments.