INFECTIONS IN IFNGR-1-DEFICIENT CHILDREN

Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly iden tified autosomal recessive inherited immune disorder. Children with IF NGR-1 deficiency exhibit a severe, profound and selective susceptibili ty to weakly virulent mycobacteria, such as bacillus Calmette-Guerin ( BCG) vaccine or environmental nontuberculous mycobacteria (NTM), This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.