MOLECULAR ANALYSIS OF THE INTERACTION BETWEEN HPV TYPE-16 E6 AND HUMAN E6-ASSOCIATED PROTEIN

Authors
DANIELS PR SANDERS CM COULSON P MAITLAND NJ
Citation
Pr. Daniels et al., MOLECULAR ANALYSIS OF THE INTERACTION BETWEEN HPV TYPE-16 E6 AND HUMAN E6-ASSOCIATED PROTEIN, FEBS letters, 416(1), 1997, pp. 6-10
Citations number
29
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
416
Issue
1
Year of publication
1997
Pages
6 - 10
Database
ISI
SICI code
0014-5793(1997)416:1<6:MAOTIB>2.0.ZU;2-W
Abstract
The complex formed between the human papillomavirus type 16 E6 protein and human E6-associated protein, which combine to ubiquitylate and de grade p53, has been studied bg chemical crosslinking. Analysis of the interactions of proteins purified from Escherichia coli as wen as prot eins expressed in insect cells indicates that, while E6 has the capaci ty to form dimers, E6 and E6-associated protein interact as two monome rs to form a heterologous dimer. (C) 1997 Federation of European Bioch emical Societies.