FACILE NUCLEOPHILIC DISPLACEMENT ON A 4-TRIAZOLYLPYRIMIDINE DEOXYNUCLEOSIDE - SINGLE-STEP SYNTHESIS OF N-ACYLATED 5-METHYLDEOXYCYTIDINES

Authors
PERBOST M SANGHVI YS
Citation
M. Perbost et Ys. Sanghvi, FACILE NUCLEOPHILIC DISPLACEMENT ON A 4-TRIAZOLYLPYRIMIDINE DEOXYNUCLEOSIDE - SINGLE-STEP SYNTHESIS OF N-ACYLATED 5-METHYLDEOXYCYTIDINES, Journal of the Chemical Society. Perkin transactions. I, (15), 1994, pp. 2051-2052
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
15
Year of publication
1994
Pages
2051 - 2052
Database
ISI
SICI code
0300-922X(1994):15<2051:FNDOA4>2.0.ZU;2-4
Abstract
A 4-triazolyl substituted pyrimidine nucleoside undergoes nucleophilic displacement with the sodium salts of amides and thiols at room tempe rature in 1,4-dioxane exclusively at the 4-position to provide a simpl e and efficient preparation of 4-N-acylated and 4-thiolated analogues, respectively.