TUMOR-TARGETED BORANES .3. SYNTHESIS OF CARBAMATE-LINKED NITROIMIDAZOLYL CARBORANES DESIGNED FOR BORON NEUTRON-CAPTURE THERAPY OF CANCER

Authors
SCOBIE M THREADGILL MD
Citation
M. Scobie et Md. Threadgill, TUMOR-TARGETED BORANES .3. SYNTHESIS OF CARBAMATE-LINKED NITROIMIDAZOLYL CARBORANES DESIGNED FOR BORON NEUTRON-CAPTURE THERAPY OF CANCER, Journal of the Chemical Society. Perkin transactions. I, (15), 1994, pp. 2059-2063
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
15
Year of publication
1994
Pages
2059 - 2063
Database
ISI
SICI code
0300-922X(1994):15<2059:TB.SOC>2.0.ZU;2-J
Abstract
Carboranes targetted to specific tumour tissues are important for boro n neutron capture therapy of cancer (BNCT), Carbamoylation of -[2-[2-( 2-nitroimidazol-1-yl)ethoxy]ethoxy]ethanol 5 and 1-(chloromethyl)-2-(2 -nitroimidazol-1-yl)ethanol 6 with carboran-1-yl isocyanate (generated in situ by a Curtius rearrangement of carborane-1-carbonyl azide) gav e the corresponding carbamate-linked nitroimidazolylcarboranes 16 and 17. A similar reaction of 4-carboranylphenyl isocyanate with 6 afforde d the corresponding carbamate 24.