EMODIN-INDUCED INHIBITION OF GROWTH AND DNA-DAMAGE IN THE HELICOBACTER-PYLORI

Studies were conducted to examine the dose effects of emodin on inhibi tion of growth versus DNA damage events in H. pylori from patients who had peptic ulcer disease. Inhibition of growth study from H. pylori d emonstrated that emodin elicited dose-dependent growth inhibition in H . pylori cultures; that is, the greater the concentration of emodin, t he greater the growth inhibition to H. pylori. However, S1 nuclease se nsitivity analysis studies revealed that emodin induced dose-dependent DNA damage in H. pylori. Collectively, these results suggest that the re was a possible relationship between the dose response to emodin and the inhibition of growth and DNA damage in H. pylori.