Dm. Obzansky et al., DEVELOPMENT AND ANALYTICAL PERFORMANCE OF AN AUTOMATED SCREENING METHOD FOR CANNABINOID ON THE DIMENSION(R) CLINICAL-CHEMISTRY SYSTEM, Journal of automatic chemistry, 19(5), 1997, pp. 169-173
A fully automated:, random access method for the determination of cann
abinoids (UTHC) was developed for the Dimension((R)) AR and XL clinica
l chemistry systems. The method utilizes Abuscreen ONLINE(R) reagents
and a multianalyte liquid calibrator containing 11-nor-Delta(9)-THC-9-
carboxylic acid. Within-run and total reproducibility, determined usin
g NCCLS protocol EP5-T2, was less than 0.6% and 1.6% CV, respectively,
at all concentrations. Calibration stability was retained for at leas
t 30 days. An extensive evaluation of non-structurally related drugs a
nd various physiological substances indicated lack of interference in
the method. No sample carry-over was observed following a specimen con
taining 1886 ng/ml 11-nor-Delta(9)-THC-9-carboxylic acid. A 99.1% agre
ement (N = 445 samples) was Sound between an EMIT(R) based method on t
he aca((R)) discrete clinical analyser and the Dimension((R)) UTHC met
hod. Dimension((R)) clinical chemistry system and aca((R)) discrete cl
inical analyser are registered trademarks of Dade International.