EFFECT OF CA2-CHANNEL BLOCKERS ON ISOPRENALINE-INDUCED DESENSITIZATION IN RAT TRACHEA()

Authors
Citation
Pp. Vassilev, EFFECT OF CA2-CHANNEL BLOCKERS ON ISOPRENALINE-INDUCED DESENSITIZATION IN RAT TRACHEA(), Life sciences, 61(21), 1997, pp. 315-320
Citations number
20
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
ISSN journal
00243205
Volume
61
Issue
21
Year of publication
1997
Pages
315 - 320
Database
ISI
SICI code
0024-3205(1997)61:21<315:EOCBOI>2.0.ZU;2-8
Abstract
Isoprenaline-induced desensitization in vitro in rat trachea was studi ed in the presence of the Ca2+-channel blockers (Ca2+-CBs) verapamil a nd nitrendipine. The concentration-response curves for isoprenaline we re determined in a noncumulative manner using carbachol as contracting agent, and then desensitization was achieved by 40-min incubation of the tracheal preparations with isoprenaline (1 mu M). The effect of ve rapamil and nitrendipine was studied by the addition of each Ca2+-CB t o the desensitizing solution. Both verapamil and nitrendipine reduced the isoprenaline-induced desensitization in the rat trachea. (C) 1997 Elsevier Science Inc.