We present a case of giant calcifying epithelioma of Malherbe (pilomat
rixoma) in the right upper arm of a 62-year-old man. It measured 18x12
x8 cm in size, making it the largest of all the cases reported previou
sly. CT clearly demonstrated a well-defined, subcutaneous mass with am
orphous calcifications. The mass showed intermediate signal intensity
on T2-weighted MR images and slight contrast uptake on contrast-enhan
ced MR images. Histopathologically, this tumor showed no aggressive or
malignant nature. The patient is without evidence of recurrence or me
tastasis 3 years following the resection.