The case of a patient with epithelioid sarcoma in the right arm is rep
orted. The diagnosis was delayed because of misinterpretation arising
from complexity in the MR findings, including a honeycomb pattern in t
he subcutaneous fat simulating lymphedema, and an intramuscular diffus
e high signal intensity on T2-weighted images without a discrete mass
lesion. The histological findings revealed that the diffuse muscular a
bnormality mainly resulted from denervation of the muscles due to peri
neural invasion by the tumor, and subcutaneous edema from lymphedema s
econdary to lymphatic tumor spread concurrent with lymphatic fibrosis.
Multiple foci of cortical erosions in the humerus, a rare manifestati
on of this tumor, were detected 6 months later.