Epidural steroid therapy is a commonly applied ''conservative'' therap
y, but it is not inherently benign. Although arachnoiditis, infection,
and meningitis have been reported, acute paraplegia has not been repo
rted as a complication of either caudal or spinal epidural steroid inj
ection. A unique case of transient, profound paralysis after epidural
steroid injection is reported here. The procedure was carried out with
out fluoroscopic control and was complicated by a puncture of the thec
al sack. Radiographic studies demonstrated a focal, space-occupying le
sion in the spinal canal at the level corresponding to the neurologic
deficit, which spontaneously resolved over the next 2-3 h. Surgical de
compression was initially considered and then deferred in favor of obs
ervation. The patient recovered motor, sensory, and bowel and bladder
function over the next 48 h. The period of recovery was consistent wit
h an acute but brief compressive injury and inconsistent with an anest
hetic effect. Radiographic studies suggest three possible explanations
: (a) inadvertent thecal penetration during injection may have produce
d an atypical anesthetic block; (b) loculation of the injected fluid m
ay have caused a transient compressive lesion; or (c) intrathecal inje
ction may have produced an iatrogenic arachnoid cyst. Although patholo
gic confirmation of the cause was not possible, the potential for this
alarming complication should be recognized by physicians prescribing
epidural steroid therapy. We do not suggest that epidural steroid ther
apy is the treatment of choice for patients with multiple back operati
ons or that it is efficacious for these patients. Our purpose is to al
ert surgeons and therapists to a rare but potentially devastating comp
lication and to provide our experience in treating it.