Cardiovascular diseases are the major cause of mortality in patients o
n hemodialysis (HD). Recently, signal averaged electrocardiography (SA
ECG) has been developed to detect venticular late potentials (LP) noni
nvasively from the body surface for identifying patients at sudden dea
th or venticular tachycardia. We performed SAECG in 42 patients before
and after HD. As a result, postdialysis total filtered QRS duration (
FQRS) was significantly increased compared with predialysis FQRS. Post
dialysis duration of low amplitude signal under 40 mu V in the latter
part of QRS (LAS40) tended to increase compared with predialysis LAS40
. Before HD, there were no patients with LP and only one patient (2.4%
) with abnormal SAECGs. In contrast, after HD, there were three patien
ts (7.1%) with LP and three more patients (7.1%) with abnormal SAECGs.
Furthermore, there was a significant correlation between the changes
in LAS40 (Delta LAS40) and those in potassium (K) (Delta K) during HD.
We further examined the relation between LAS40 and the concentration
of K, by comparing the correlation coefficient between patients in the
high-K group (predialysis K greater than or equal to 5.0 mEq/L; 20 pa
tients) and those in the low-K group (predialysis K < 5.0 mEq/L; 22 pa
tients). In the low-K group, there was no significant correlation betw
een Delta LAS40 and Delta K. However, in the high-K group, there was a
significant correlation between Delta LAS40 and Delta K. In conclusio
n, SAECG indices worsened during HD, and an insufficient decrement of
serum potassium by HD is suggested to have been an arrhythmogenic fact
or in the high-K group.