A. Timuragaoglu et al., ANEMIA AND THROMBOCYTOPENIA DUE TO PARVOVIRUS B-19 INFECTION IN A PREGNANT WOMAN, Journal of medicine, 28(3-4), 1997, pp. 245-249
Anemia and thrombocytopenia in a patient with parvovirus B-19 and hepa
titis C infection is reported. A seven month-pregnant 20 year-old pati
ent had been first found to be anemic and thrombocytopenic 40 days bef
ore admission to our hospital and she had been given methylprednisolon
e and red cell transfusions. She gave birth to a healthy baby after on
ly eight months of pregnancy. Ten days after delivery she was admitted
to our hospital because of anemia and thrombocytopenia which did not
respond to treatment. On admission, the blood count showed hemoglobin
8.1 g/dL, hematocrit 23.7%, white blood cells 11200/mu L, platelets 10
00/mu L, and reticulocytes 0.6%. Bone marrow smear and biopsy revealed
erytroblastopenia and the absence of megakaryocytes. Liver enzymes we
re also high (alanine aminotransferase 1469 Units/L and aspartate amin
otransferase 981 Units/L). In serologic studies PVB-19 IgM was found t
o be positive and hepatitis C virus RNA was detected. Red cell and pla
telet values returned to normal levels after cessation of methylpredni
solone and concomitantly PVB-19 IgG was found positive in association
with IgM in repeated determinations. PVB-19 was thought to be responsi
ble for both anemia and thrombocytopenia.