Mt. Hsieh et al., BIPHASIC EFFECTS OF PU-CHUNG-I-CHI-TANG ON SEDATION AND EXCITATION, The American journal of Chinese medicine, 25(3-4), 1997, pp. 343-350
The biphasic effects of Pu-Chung-I-Chi-Tang (PCT) on sedation and exci
tation in acute treatment or after one-week consecutive treatment were
studied. The results indicated that PCT produces sedation in acute tr
eatment and excitation after one-week consecutive treatment. The sedat
ive mechanism of PCT in acute treatment might be due to an increase in
serotonergic activity and a decrease in dopaminergic activity. Howeve
r, the excitatory mechanism of PCT after one-week consecutive treatmen
t might involve the increase in dopaminergic activity and the decrease
in serotonergic activity.