G. Atlan et al., RECONSTRUCTION OF HUMAN MAXILLARY DEFECTS WITH NACRE POWDER - HISTOLOGICAL EVIDENCE FOR BONE REGENERATION, Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 320(3), 1997, pp. 253-258
The defective areas in the premolar-molar region of maxillary alveolar
bone of eight patients were reconstructed using powdered nacre from t
he giant oyster Pinctada maxima. Histological, microradiographic and p
olarized light studies of drill biopsies taken 6 months postoperativel
y showed that nacre was tightly bound to newly-formed bone. The nacre
was gradually and centripetally biodissolved and replaced with immatur
e and then mature lamellar bone. These results are in agreement with o
ur previous experimental in vitro data indicating that nacre has good
osteogenic properties.