POROUS-TYPE TRACHEAL PROSTHESIS SEALED WITH COLLAGEN SPONGE

Citation
M. Teramachi et al., POROUS-TYPE TRACHEAL PROSTHESIS SEALED WITH COLLAGEN SPONGE, The Annals of thoracic surgery, 64(4), 1997, pp. 965-969
Citations number
20
Categorie Soggetti
Surgery,"Cardiac & Cardiovascular System
ISSN journal
00034975
Volume
64
Issue
4
Year of publication
1997
Pages
965 - 969
Database
ISI
SICI code
0003-4975(1997)64:4<965:PTPSWC>2.0.ZU;2-B
Abstract
Background. Reconstruction of a long section of the trachea is clinica lly problematic. Tracheal reconstructions using prostheses have met wi th limited success due to local infection, hemorrhage, luminal stenosi s and prosthesis dislocation. Methods. We have designed a porous type of tracheal prosthesis in which the mesh is sealed with collagen spong e. We used this prosthesis (50 mm in length) to reconstruct the cervic al trachea in 10 mongrel dogs and evaluated its efficacy. Results. One dog died due to an accident with anesthesia at 6 weeks and 1 of suffo cation at 10 weeks. The other 8 dogs had an uneventful postoperative c ourse until they were killed between 6 and 24 months after implantatio n. At sacrifice, all the prostheses had become completely incorporated into the host. Microscopic examination revealed advanced formation of a new epithelial lining in 1 dog at 6 months, and a confluent epithel ial lining was observed in another dog at 12 months. Central stenosis was not significant in any of the animals. Conclusions. This tracheal prosthesis gives good results in canine tracheal reconstruction, and a ppears very promising for the clinical repair of tracheal defects. (C) 1997 by The Society of Thoracic Surgeons.