VALPROATE-ASSOCIATED ENCEPHALOPATHY - A CASE-REPORT - REVIEW OF THE LITERATURE

Valproate-associated encephalopathy is well known of to neurologists. It produces stupor or delirium, sometimes associated with disturbances in gait and motor coordination. EEG is characterized by a diffuse the ta-delta background slowing, without seizure activity. A psychiatric c ase report in an epileptic subject, remitted from a melancholic episod e with psychotic features, illustrates this risk and its possible etio logies. Some delirious states during treatment with valpromide, valpro ate's pro-drug, might share the same origin.