SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 1-BENZYLBENZIMIDAZOLIUM CHLORIDES

Authors
PERNAK J ARNDT A BRYCKI B
Citation
J. Pernak et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 1-BENZYLBENZIMIDAZOLIUM CHLORIDES, Archiv der pharmazie, 330(8), 1997, pp. 253-258
Citations number
9
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
330
Issue
8
Year of publication
1997
Pages
253 - 258
Database
ISI
SICI code
0365-6233(1997)330:8<253:SAAAON>2.0.ZU;2-#
Abstract
1-Benzylbenzimidazole reacts with chloromethylalkyl ethers or sulfides or chloromethylcycloalkyl ethers to produce 3-alkoxymethyl-1-benzylbe nzimidazolium or 3-alkylthiomethyl-1 -benzylbenzimidazolium or 1-benzy l-3-cycloalkoxymethylbenzimidazolium chlorides in very good yields. Al l the 1-benzylbenimid azolium chlorides showed antimicrobial activity. The relationship between chemical structure and antimicrobial activit y was analyzed by quantitative structure-activity relationships (QSAR) .