COMPLETE CYTOGENETIC BUT NOT MOLECULAR REMISSION IN A PATIENT WITH MYELOID BLAST CRISIS OF CHRONIC MYELOID-LEUKEMIA TREATED WITH CARBOPLATIN AND ARA-C

Authors
PEREZSIMON JA CABALLERO MD HERNANDEZRIVAS JM CHILLON C GARCIAISIDORO M SANMIGUEL JF
Citation
Ja. Perezsimon et al., COMPLETE CYTOGENETIC BUT NOT MOLECULAR REMISSION IN A PATIENT WITH MYELOID BLAST CRISIS OF CHRONIC MYELOID-LEUKEMIA TREATED WITH CARBOPLATIN AND ARA-C, Haematologica, 82(5), 1997, pp. 604-605
Citations number
10
Categorie Soggetti
Hematology
Journal title
Haematologica → ACNP
ISSN journal
03906078
Volume
82
Issue
5
Year of publication
1997
Pages
604 - 605
Database
ISI
SICI code
0390-6078(1997)82:5<604:CCBNMR>2.0.ZU;2-3
Abstract
We report on a patient diagnosed with myeloid BC-CML in which a comple te cytogenetic remission confirmed by FISH assay was obtained after th erapy with carboplatin-ARA-C. However, RT-PCR analysis showed persiste nce of the p210 bcr-abl translocation. Accordingly, the level of resid ual malignant cells should be between 10(-2) and 10(-6). Autologous st em cell transplantation was performed, but relapse occurred 11 months after blast crisis. This case supports the effectiveness of a carbopla tin-ARA-C protocol in BC-CML in order to induce cytogenetic remissions . (C) 1997, Ferrata Storti Foundation.