INCREASED LOVASTATIN FORMATION BY ASPERGILLUS-TERREUS USING REPEATED FED-BATCH PROCESS

Lovastatin biosynthesis with Aspergillus terreus in batch fermentation reached 160 U/l in 161 h at pH 6.8 and a dissolved O-2 tension mainta ined at 70%. At the end of repeated fed batch fermentations, the yield of lovastatin was increased by 37% though this took over twice as lon g as in the batch fermentation.