MODEL-BASED DESIGN OF BIOCHEMICAL PROCESSES - SIMULATION STUDIES AND EXPERIMENTAL TESTS

A simple design procedure is proposed that can be used to enhance the performance of a biological cultivation process. The model-supported m ethod starts with a simple model. This is used to design first experim ent, i.e., to calculate such a control profile that improves the proce ss performance. The results of the experiment are then used to update the model and subsequently the control profiles. The procedure was fir st tested at simulated Saccharomyces cerevisiae and Penicillum chrysog enum cultivation processes and then practically applied to optimize an E. coli cultivation.