Tw. Wehbe et al., PROSTATE-SPECIFIC ANTIGEN RESPONSE TO WITHDRAWAL OF MEGESTROL-ACETATEIN A PATIENT WITH HORMONE-REFRACTORY PROSTATE-CANCER, Mayo Clinic proceedings, 72(10), 1997, pp. 932-934
Clinically significant responses after withdrawal of flutamide in pati
ents with hormone-refractory prostate cancer (HRPC) are well documente
d. Failure to recognize this syndrome of response results in potential
morbidity due to salvage therapy, confusion in interpretation of dise
ase state, and introduction of a possible source of error in clinical
trials, In this case report, we describe a patient with HRPC whose pro
state-specific antigen levels decreased substantially in response to w
ithdrawal of megestrol acetate. Such a response should be considered w
hen megestrol acetate is used in the treatment of HRPC.