Many substances have historically been used to address facial soft tis
sue defects. Currently in the United States autologous fat and injecta
ble bovine collagen are the most commonly utilized injectable fillers.
Additionally, the judicious application of BOTOX in the upper face as
well as neck has all but revolutionized the use of filling agents in
these locales. While ether agents are briefly mentioned, this is an in
-depth review of the characteristics and application of autologous fat
, bovine collagen.