SUCCESSFUL TREATMENT OF DISSEMINATED CENTRAL NERVOUS ASPERGILLOSIS INA PATIENT WITH ACUTE MYELOBLASTIC-LEUKEMIA

Invasive opportunistic mycoses are common complications in patients su ffering from hematological disorders. Brain abscesses in the immunocom promised host are known to be most frequently caused by fungi of the A spergillus species and are often associated with concomitant pulmonary disease. As the penetration of the currently available antifungal age nts into the brain tissue is limited, only very few patients have been described to survive this life-threatening condition. We report the c ase of a 62 year old female patient who presented with multiple asperg illus brain abscesses during prolonged neutropenia following induction chemotherapy for acute myeloblastic leukemia and was successfully tre ated with high dose (8 mg/kg/day) liposomal amphotericin B.