DIAGNOSTIC AND PREDICTIVE VALUE OF AUDITORY-EVOKED RESPONSES IN PRETERM INFANTS .2. AUDITORY-EVOKED RESPONSES

In this study, the diagnostic and predictive value of brainstem, middl e latency, and cortical auditory evoked responses (BMC-AERs) obtained in the neonatal period in 81 preterm infants was assessed in relation to neurodevelopmental outcome. The pre term infants were neonatally cl assified according to risk category and gestational age. The BMC-AERs were analyzed with respect to detectability, latencies, and amplitudes as well as derived latency and amplitude measures. At 5 y of age the neurodevelopmental outcome was assessed from neurologic and neuropsych ologic evaluations. The results showed that BMC-AER differences mainly correlated with risk category (low risk/high risk) and to some extent with degree of prematurity. In view of these findings the degree of p rematurity and the effect of risk category have to be taken into accou nt, when BMC-AERs are applied in the preterm period to predict neurode velopmental outcome. In this study the BMC-AERs for infants with abnor mal neurodevelopmental outcome were scarcely distinguishable from the BMC-AERs for infants with normal neurodevelopmental outcome. Thus far, this and previous reports have indicated that BMC-AERs in preterm inf ants are useful in maturational studies and with infants showing sympt oms related to lesions or dysfunction of the peripheral and/or central auditory system. For predicting neurodevelopmental outcome in preterm infants, BMC-AERs are of limited clinical value.