Bb. Herlofson et al., ORAL MUCOSAL SIDE-EFFECTS OF CYTOTOXIC CHEMOTHERAPY OF TESTICULAR CANCER - A RETROSPECTIVE STUDY, European journal of oral sciences, 105(5), 1997, pp. 523-526
Cancer chemotherapy often leads to injury of normal cells. Adverse eff
ects on oral mucosa have been documented for several cytotoxic treatme
nt regimens. The aim of the present retrospective study was to evaluat
e incidence and degree of oral soft tissue side-effects of a cisplatin
-based chemotherapy regimen used for treating testicular cancer. The s
tudy was based upon a questionnnaire mailed to 56 consecutive patients
treated at the Norwegian Radium Hospital. A total of 39 individuals j
oined the study, as 2 patients refused and 15 did not reply. The patie
nts were divided into two groups, a case group (24 individuals) having
received 4-7 cycles of cisplatin-based chemotherapy in addition to su
rgery, and a control group (15 individuals) treated with surgery alone
. The study revealed that 62% of the patients in the chemotherapy grou
p developed adverse soft tissue reactions, with mucositis and pain as
chief complaints, whereas none in the control group experienced any mu
cosal complications.