THE HLA A1-B8 HAPLOTYPE EXTENDS 6 MB BEYOND HLA-A - ASSOCIATIONS BETWEEN HLA-A, HLA-B, HLA-F AND 15 MICROSATELLITE MARKERS

Authors
WORWOOD M CHOWDHURY RR ROBSON KJH POINTON J SHEARMAN JD DARKE C
Citation
M. Worwood et al., THE HLA A1-B8 HAPLOTYPE EXTENDS 6 MB BEYOND HLA-A - ASSOCIATIONS BETWEEN HLA-A, HLA-B, HLA-F AND 15 MICROSATELLITE MARKERS, Tissue antigens, 50(5), 1997, pp. 521-526
Citations number
20
Categorie Soggetti
Immunology,"Cell Biology
Journal title
Tissue antigens → ACNP
ISSN journal
00012815
Volume
50
Issue
5
Year of publication
1997
Pages
521 - 526
Database
ISI
SICI code
0001-2815(1997)50:5<521:THAHE6>2.0.ZU;2-#
Abstract
Allele frequencies for HLA-A, B and F and I5 microsatellite markers lo cated from 100 kb telomeric to HLA-A to 6 Mb telomeric have been deter mined in a group of 60 blood donors. Linkage disequilibrium analysis r evealed significant haplotype associations even after correction for t he number of comparisons made. The HLA-A1, B8 haplotype extends as far as D6S276 (6.0 Mb telomeric to HLA-A). It is important to realize tha t this common haplotype extends beyond the HLA region, especially when evaluating haplotype associations with particular disorders.