M. Worwood et al., THE HLA A1-B8 HAPLOTYPE EXTENDS 6 MB BEYOND HLA-A - ASSOCIATIONS BETWEEN HLA-A, HLA-B, HLA-F AND 15 MICROSATELLITE MARKERS, Tissue antigens, 50(5), 1997, pp. 521-526
Allele frequencies for HLA-A, B and F and I5 microsatellite markers lo
cated from 100 kb telomeric to HLA-A to 6 Mb telomeric have been deter
mined in a group of 60 blood donors. Linkage disequilibrium analysis r
evealed significant haplotype associations even after correction for t
he number of comparisons made. The HLA-A1, B8 haplotype extends as far
as D6S276 (6.0 Mb telomeric to HLA-A). It is important to realize tha
t this common haplotype extends beyond the HLA region, especially when
evaluating haplotype associations with particular disorders.