HLA DRB1-DQA1-DQB1 HAPLOTYPE DIVERSITY IN 2 AFRICAN POPULATIONS

Authors
SCHNITTGER L MAY J LOELIGER CC GALLIN MY ERTTMANN KD BIENZLE U KREMSNER PG MEYER CG
Citation
L. Schnittger et al., HLA DRB1-DQA1-DQB1 HAPLOTYPE DIVERSITY IN 2 AFRICAN POPULATIONS, Tissue antigens, 50(5), 1997, pp. 546-551
Citations number
23
Categorie Soggetti
Immunology,"Cell Biology
Journal title
Tissue antigens → ACNP
ISSN journal
00012815
Volume
50
Issue
5
Year of publication
1997
Pages
546 - 551
Database
ISI
SICI code
0001-2815(1997)50:5<546:HDHDI2>2.0.ZU;2-P
Abstract
HLA class II DRB1-DQA1-DQB1 haplotypic polymorphism was determined in 120 Liberian and 230 Gabonese individuals. In our study groups, the nu mber of allelic variants observed for each locus was similar to that f ound in non-African populations. However, 39 novel haplotypes and seve ral yet unrecognized DRB1-DQA1 and DQA1-DQB1 combinations were identif ied. The extent of HLA-haplotypic variability in Africans appears to r esult from the high degree of allele combinations rather than from all elic polymorphism.