INTERACTION OF HUMAN RECOMBINATION PROTEINS RAD51 AND RAD54

Authors
GOLUB EI KOVALENKO OV GUPTA RC WARD DC RADDING CM
Citation
Ei. Golub et al., INTERACTION OF HUMAN RECOMBINATION PROTEINS RAD51 AND RAD54, Nucleic acids research, 25(20), 1997, pp. 4106-4110
Citations number
33
Categorie Soggetti
Biology
Journal title
Nucleic acids research → ACNP
ISSN journal
03051048
Volume
25
Issue
20
Year of publication
1997
Pages
4106 - 4110
Database
ISI
SICI code
0305-1048(1997)25:20<4106:IOHRPR>2.0.ZU;2-2
Abstract
The cDNA for human protein HsRad54, which is a structural homolog of S accharomyces cerevisiae recombination/repair protein Rad54, was cloned and expressed in Escherichia coil, As demonstrated by analysis in vit ro and in vivo, HsRad54 protein interacts with human Rad51 recombinase . The interaction is mediated by the N-terminal domain of HsRad54 prot ein, which interacts with both free and DNA-bound HsRad51 protein.