PROSTAGLANDIN MODULATION OF MOUSE AND HUMAN SPERM CAPACITATION

Authors
HERRERO MB VIGGIANO JM BOQUET M GIMENO MAF
Citation
Mb. Herrero et al., PROSTAGLANDIN MODULATION OF MOUSE AND HUMAN SPERM CAPACITATION, Prostaglandins, leukotrienes and essential fatty acids, 57(3), 1997, pp. 279-284
Citations number
20
Categorie Soggetti
Endocrynology & Metabolism",Biology
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
57
Issue
3
Year of publication
1997
Pages
279 - 284
Database
ISI
SICI code
0952-3278(1997)57:3<279:PMOMAH>2.0.ZU;2-0
Abstract
To determine whether prostaglandins produce a capacitation and/or acro some reaction, the effect of prostaglandins on capacitated mouse sperm atozoa and the effect of prostaglandin pre-incubation on human and mou se spermatozoa were studied. Prostaglandins did not induce an acrosome reaction in capacitated mouse sperm. PGE(1) pre-incubation in a prote in-free medium enhanced acrosome loss of mouse sperm challenged with A -23187 or solubilized mouse zona pellucida. Human sperm were pre-incub ated in media containing prostaglandins, and an acrosome reaction was induced with calcium ionophore or human follicular fluid. PGE(1) pre-i ncubation enhanced acrosome loss by human sperm when the action was in duced with calcium ionophore, but had no effect on follicular fluid in duction. We conclude that PGE(1) acts as a capacitating factor in vitr o for mouse spermatozoa, and enhances acrosome-reaction induction with calcium ionophore in human spermatozoa.