HEPATOTOXICITY OF DIAZEPAM - STRUCTURAL AND TRACE-METAL STUDIES IN RAT

Citation
S. Chatterjee et al., HEPATOTOXICITY OF DIAZEPAM - STRUCTURAL AND TRACE-METAL STUDIES IN RAT, Biological trace element research, 57(3), 1997, pp. 239-250
Citations number
12
Categorie Soggetti
Biology
ISSN journal
01634984
Volume
57
Issue
3
Year of publication
1997
Pages
239 - 250
Database
ISI
SICI code
0163-4984(1997)57:3<239:HOD-SA>2.0.ZU;2-Y
Abstract
Studies of effects of diazepam on liver parenchyma are very scanty. In this study, adult albino rats were treated with diazepam in two diffe rent doses (0.25 mg and 0.30 mg/kg body wt) daily for 30 and 60 d. Thr ough light microscopy and electron microscopy, prenecrotic and necroti c changes were noted in the high-dose group. Trace metal analysis indi cated that zinc (Zn) was reduced by 30 and 60 day under both the doses , whereas iron (Fe) and copper (Cu) were reduced significantly in thes e groups only after 60 d of treatment. This reduction in metal content s may have some correlations with necrotic changes in liver parenchyma .