COMPARATIVE EFFECTS OF SELENITE AND SELENITE ON THE GLUTATHIONE-RELATED ENZYMES ACTIVITY IN PIG-BLOOD PLATELETS

The effects of inorganic selenium (Se) compounds (sodium selenite and selenate) on the activities of glutathione-related enzymes (glutathion e peroxidase, glutathione-S-transferase [GST] and glutathione reductas e [GR]) in pig blood platelets were investigated in vitro. GST activit y in blood platelets treated with 10(-4)M of selenite was reduced to 5 0%, whereas no decrease GST activity was observed after the treatment of platelets with the same dose of selenate. In platelets incubated wi th physiological doses (10(-7) and 10(-6)M) of Se compounds, the activ ity of glutathione peroxidase (GSH-Px) was enhanced (about 20%). GR ac tivity after the exposure of platelets to tested Se compounds was unaf fected.