Objects. An earlier paper estimated the per-case and national incidenc
e costs of Alzheimer's disease for 1983. This paper updates the estima
tes of costs per case to 1991 and presents new national prevalence est
imates of the economic and social costs of the disease. Methods, All d
ata for the cost estimates were taken from published sources or provid
ed by other researchers. Results. At midrange values of the estimated
cost and epidemiological parameters, the discounted (at 4%) direct and
total costs of Alzheimer's disease were $47581 and $173932 per case,
respectively. The estimated 1991 national direct and total prevalence
costs were $20.6 billion and S67.3 billion, respectively. Assuming con
servatively that the prevalence of the disease remains constant, the e
stimated discounted present values of the direct and total costs of al
l current and future generations of Alzheimer's patients are $536 bill
ion and $1.75 trillion, respectively. Conclusions. The $536 billion an
d $1.75 trillion figures are minimum estimates of the long-term dollar
losses to the US economy in 1991 caused by Alzheimer's disease.