PANCREATIC NEUROENDOCRINE CARCINOMA METASTATIC TO THE BREAST AS PART OF THE MULTIPLE ENDOCRINE NEOPLASIA TYPE-1 SYNDROME

Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the br east in a patient with possible multiple endocrine neoplasia type 1. T he diagnosis was supported by histological examination, immunohistoche mistry, and ultrastructural analysis. This observation emphasizes the importance of clinical data for an accurate diagnosis, especially duri ng intraoperative examination. When pathologists are faced with an unu sual breast tumor larger than 2 cm, we would recommend freezing and/or saving pieces of tissue for ultrastructural analysis, which might hel p in the diagnosis.