STEREOSELECTIVE AMINATION OF CHIRAL ENOLATES - SYNTHESIS OF CHIRAL KEY INTERMEDIATES FOR BETA-LACTAM ANTIBIOTICS

Authors
CATIVIELA C DIAZDEVILLEGAS MD GALVEZ JA
Citation
C. Cativiela et al., STEREOSELECTIVE AMINATION OF CHIRAL ENOLATES - SYNTHESIS OF CHIRAL KEY INTERMEDIATES FOR BETA-LACTAM ANTIBIOTICS, Tetrahedron : asymmetry, 5(8), 1994, pp. 1465-1468
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
8
Year of publication
1994
Pages
1465 - 1468
Database
ISI
SICI code
0957-4166(1994)5:8<1465:SAOCE->2.0.ZU;2-K
Abstract
Stereoselective enolate trapping of lithium hexylsulfamoylisobornyl-2- cyano-3-phenylpropanoate with O-(diphenylphosphinyl) hydroxylamine fol lowed by appropriate reduction, hydrolysis, and cyclisation processes allows the asymmetric synthesis of (S)-3-amino-3-benzyl-2-azetidinone.