A CONVENIENT SYNTHESIS OF 5-HYDROXY-2'-DEOXYCYTIDINE PHOSPHORAMIDITE AND ITS INCORPORATION INTO OLIGONUCLEOTIDES

Authors
ROMIEU A GASPARUTTO D MOLKO D CADET J
Citation
A. Romieu et al., A CONVENIENT SYNTHESIS OF 5-HYDROXY-2'-DEOXYCYTIDINE PHOSPHORAMIDITE AND ITS INCORPORATION INTO OLIGONUCLEOTIDES, Tetrahedron letters, 38(43), 1997, pp. 7531-7534
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
43
Year of publication
1997
Pages
7531 - 7534
Database
ISI
SICI code
0040-4039(1997)38:43<7531:ACSO5P>2.0.ZU;2-C
Abstract
Oligonucleotides containing 5-hydroxy-2'-deoxycytidine (2) have been s ynthesized using the phosphoramidite chemistry. The presence and the i ntegrity of the modified nucleoside in the synthetic oligomers were co nfirmed by electrospray mass spectrometry and chromatoghraphic analysi s of enzymatic digestion coupled with UV detection. (C) 1997 Elsevier Science Ltd.