ASYMMETRIC CARBOXYLATION IN THE SYNTHESIS OF L-METHIONINE - A NEW TOOL FOR C-11 CHEMISTRY

Authors
JEANJEAN F PEROL N GORE J FOURNET G
Citation
F. Jeanjean et al., ASYMMETRIC CARBOXYLATION IN THE SYNTHESIS OF L-METHIONINE - A NEW TOOL FOR C-11 CHEMISTRY, Tetrahedron letters, 38(43), 1997, pp. 7547-7550
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
43
Year of publication
1997
Pages
7547 - 7550
Database
ISI
SICI code
0040-4039(1997)38:43<7547:ACITSO>2.0.ZU;2-F
Abstract
L-methionine is obtained in good yield and high e.e. by using the carb oxylation of an enantiopure alpha-lithio oxazolidinone prepared by tin -lithium exchange. The entire process from alpha-stannyl oxazolidinone takes 35-40mn, time which is compatible with the use of (CO2)-C-11 in radioactive chemistry directed to PET imaging. (C) 1997 Published by Elsevier Science Ltd.