SYNTHESIS OF CYCLODEXTRIN DERIVATIVES CARRYING BIO-RECOGNIZABLE SACCHARIDE ANTENNAE

Authors
KASSAB R FELIX C PARROTLOPEZ H BONALY R
Citation
R. Kassab et al., SYNTHESIS OF CYCLODEXTRIN DERIVATIVES CARRYING BIO-RECOGNIZABLE SACCHARIDE ANTENNAE, Tetrahedron letters, 38(43), 1997, pp. 7555-7558
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
43
Year of publication
1997
Pages
7555 - 7558
Database
ISI
SICI code
0040-4039(1997)38:43<7555:SOCDCB>2.0.ZU;2-W
Abstract
The use of coupling saccharide antenna onto cyclodextrins allows mobil ity for the biologically active galactose head group, and allows the r ecognition process by the lectin (KbCWL). This paper reports a chemica l synthesis of beta-CD derivatives using spacer arms 3, 4, 5, 6 and 9 carbon atoms. Preliminary results suggested that recognition is strong ly dependent on the length of the spacer chain between the cyclodextri n and the sugar head group. (C) 1997 Elsevier Science Ltd.