FACILE SYNTHESIS OF (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE, AN ISOTYPE-SELECTIVE AGONIST OF METABOTROPIC GLUTAMATE RECEPTORS

Authors
MA DW MA ZC
Citation
Dw. Ma et Zc. Ma, FACILE SYNTHESIS OF (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE, AN ISOTYPE-SELECTIVE AGONIST OF METABOTROPIC GLUTAMATE RECEPTORS, Tetrahedron letters, 38(43), 1997, pp. 7599-7602
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
43
Year of publication
1997
Pages
7599 - 7602
Database
ISI
SICI code
0040-4039(1997)38:43<7599:FSO(AI>2.0.ZU;2-S
Abstract
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine (L-CCG-I) was synthesized i n 12 steps and 14% overall yield by using Sharpless's asymmetric dihyd roxylation reaction and stereochemically controlled cyclopropanation a s key steps. (C) 1997 Elsevier Science Ltd.