EFFECT OF TOPICAL APPLICATION OF A FIBRIN-FIBRONECTIN SEALING SYSTEM ON HEALING RESPONSE FOLLOWING PERIODONTAL SURGICAL-PROCEDURES

The purpose of these controlled clinical trials was to evaluate the ef fect of a fibrin-fibronectin sealing system (FFSS) application on peri odontal wound healing. Treatment outcomes following periodontal surger y were investigated by selecting different surgical procedures where w ound stability was affected by defect anatomy, surface treatment, flap management and adjunctive application of wound-stabilising devices. I n each patient, treatment modalities were randomly assigned according to a split-mouth design. In the first trial, 11 patients presenting wi th a pair of moderate to severe supra-alveolar defects were treated wi th flap debridement surgery with or without tetracycline HCl (TTC) roo t conditioning and FFSS application. In the second trial, 11 patients presenting with a pair of buccal gingival recession defects were treat ed with coronally positioned flap procedure and TTC root conditioning with and without FFSS application. In the third trial, 8 patients pres enting with a pair of buccal gingival recession defects were treated w ith coronally positioned flap procedure, TTC root conditioning and tef lon membrane with and without FFSS application. Conventional probing r ecordings, including probing depth, clinical attachment level and rece ssion depth, were made immediately before surgery and 6 months postsur gery. Overall, the results indicated that periodontal healing followin g surgery resulted in a clinically and statistically significant impro vement in the defect, and that the adjunctive application of FFSS prod uced limited to no enhancement of treatment outcome.