SYNTHESIS, ANTILEUKEMIC EVALUATION AND PEROXIDATING ABILITY OF HETEROSUBSTITUTED ANTHRACENE-9,10-DIONE ANALOGS - AMINOALKYL)AMINO]NAPHTHO[2,3-D]THIAZOLE-4,9-DIONES AND )AMINO]NAPHTHO[2,3-C][1,2,5]THIADIAZOLE-4,9-DIONES

Authors
DZIEDUSZYCKA M STEFANSKA B TARASIUK J MARTELLI S BONTEMPSGRACZ M BOROWSKI E
Citation
M. Dzieduszycka et al., SYNTHESIS, ANTILEUKEMIC EVALUATION AND PEROXIDATING ABILITY OF HETEROSUBSTITUTED ANTHRACENE-9,10-DIONE ANALOGS - AMINOALKYL)AMINO]NAPHTHO[2,3-D]THIAZOLE-4,9-DIONES AND )AMINO]NAPHTHO[2,3-C][1,2,5]THIADIAZOLE-4,9-DIONES, European journal of medicinal chemistry, 29(7-8), 1994, pp. 561-567
Citations number
38
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
29
Issue
7-8
Year of publication
1994
Pages
561 - 567
Database
ISI
SICI code
0223-5234(1994)29:7-8<561:SAEAPA>2.0.ZU;2-K
Abstract
The syntheses of a number of heterosubstituted ametantrone analogues, 5,8-bis[(aminoalkyl)amino]naphtho[2,3-d]thia- zole-4,9-diones and 5,8- bis[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones, ha ve been performed. It was evidenced that this modification in the chro mophore moiety has a negative effect on antileukemic activity. This mo dification also favors the affinity of the compounds toward NADH dehyd rogenase and influences the redox potential.