HYPERTRIGLYCERIDEMIA, BUT NOT HYPERCHOLESTEROLEMIA, IS ASSOCIATED WITH THE ALTERATIONS OF FIBRINOLYTIC SYSTEM

Derangements of the blood coagulation-fibrinolytic system are thought to be associated with the development of cardiovascular disease. Previ ous studies have identified the alterations in patients with advanced atherosclerosis, however, studies on subjects without apparent cardiov ascular complications are scarce. To evaluate the potential risk of th rombosis, we examined the serum lipid levels and fibrinolytic paramete rs in 54 subjects of different types of primary hyperlipoproteinemia ( HL) and 18 normolipidemic controls. Plasma tissue-type plasminogen act ivator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen le vels were significantly higher in type IV HL than in the controls. Ser um triglyceride concentrations were correlated with t-PA (r=0.537, p<0 .01) and PAI-1 (r=0.249, p<0.05) antigen levels, while serum cholester ol levels did not. The current study demonstrated that hypertriglyceri demia, but not hypercholesterolemia, is associated with the alteration s of fibrinolytic system.