CYTOGENETIC STUDY OF 23 PRIMARY SQUAMOUS-CELL CARCINOMAS OF THE LUNG

Fifty-seven primary squamous cell carcinomas of the lung were analyzed cytogenetically. Karyotyping was possible in seven cases, and chromos ome counting without detailed analysis was possible in 16 other cases. The results suggested that structural chromosome rearrangements relat ed to the short arms of chromosomes 1(5/7), 9(3/7), and 11(6/7), and t he long arms of chromosomes 6(4/7) and 7(6/7) may be the primary and n on-random chromosome defects which are closely associated with human l ung squamous cell carcinoma. These primacy and non-random chromosome d efects are believed to confer a proliferative advantage to cells carry ing them, and to be involved in the pathogenesis of human lung squamou s cell carcinoma. (C) Elsevier Science Inc., 1997.